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vinorelbine

Pronunciation: vin OR el been

Brand: Navelbine

What is the most important information I should know about vinorelbine?

Vinorelbine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing.

What is vinorelbine?

Vinorelbine is used to treat non-small cell lung cancer.

Vinorelbine is sometimes used in combination with other cancer medications.

Vinorelbine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving vinorelbine?

You should not be treated with vinorelbine if you are allergic to it, or if you have severely low white blood cell counts.

Tell your doctor if you have ever had:

  • liver disease;
  • bone marrow suppression;
  • a nerve disorder; or
  • radiation therapy or other cancer treatments.

Vinorelbine can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use vinorelbine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using vinorelbine.

Vinorelbine can damage sperm and may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because vinorelbine can harm an unborn baby.

You should not breastfeed while using vinorelbine, and for at least 9 days after your last dose.

How is vinorelbine given?

Vinorelbine is given as an infusion into a vein. A healthcare provider will give you this injection.

Vinorelbine is usually given once every 7 days to 6 weeks. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vinorelbine is injected.

Vinorelbine can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your vinorelbine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include white patches or sores in your mouth or throat, painful swallowing, heartburn, severe constipation, and stomach pain.

What should I avoid while receiving vinorelbine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using vinorelbine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of vinorelbine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe constipation, stomach pain, bloody or black stools;
  • numbness, tingling, muscle weakness;
  • pain, redness, numbness, and peeling skin on your hands or feet;
  • new or worsening cough, wheezing, chest tightness, trouble breathing;
  • dark urine, jaundice (yellowing of the skin or eyes);
  • pain, burning, irritation, or skin changes where the injection was given; or
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Vinorelbine can cause severe constipation. Talk with your doctor about ways to avoid constipation while you are being treated with vinorelbine.

Common side effects may include:

  • nausea, vomiting, constipation;
  • weakness;
  • numbness or tingling in your hands or feet;
  • low blood cell counts;
  • abnormal liver function tests; or
  • pain, redness, bruising, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect vinorelbine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect vinorelbine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about vinorelbine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 7.01. Revision date: 9/24/2019.

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