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ceftolozane and tazobactam

Pronunciation: sef TOL oh zane and TAZ oh BAK tam

Brand: Zerbaxa

What is the most important information I should know about ceftolozane and tazobactam?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is ceftolozane and tazobactam?

Ceftolozane and tazobactam is a combination antibiotic that is used to treat certain bacterial infections of the lungs, stomach, or urinary tract.

Ceftolozane and tazobactam is sometimes given in combination with another antibiotic medicine.

Ceftolozane and tazobactam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using ceftolozane and tazobactam?

You should not use this medicine if you are allergic to ceftolozane or tazobactam, or if you are allergic to similar antibiotics, such as:

  • penicillin antibiotics --amoxicillin, ampicillin, dicloxacillin, oxacillin, penicillin, ticarcillin, Amoxil, Moxatag, Augmentin, Principen, and others; or
  • cephalosporin antibiotics --cefdinir, cefprozil, cefuroxime, cephalexin, Ceftin, Cefzil, Keflex, Omnicef, and others.

Tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

How is ceftolozane and tazobactam given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. This medicine is sometimes given for up to 14 days, depending on the type of infection being treated.

Ceftolozane and tazobactam is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Ceftolozane and tazobactam must be mixed with a liquid (diluent) and then further diluted with another liquid in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ceftolozane and tazobactam will not treat a viral infection such as the flu or a common cold.

Store the unmixed ceftolozane and tazobactam powder in a refrigerator. Protect from light.

After you mix the powder with the first diluent, store this mixture at room temperature for up to 1 hour before further mixing it into the IV bag.

Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature, or within 7 days if kept in a refrigerator. Throw away any unused mixture that has not been used within these times.

Do not freeze the mixed or unmixed medicine.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of ceftolozane and tazobactam.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using ceftolozane and tazobactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What are the possible side effects of ceftolozane and tazobactam?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain;
  • diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
  • symptoms of bleeding in the brain --sudden numbness or weakness, problems with vision or speech.

Side effects may be more likely in older adults.

Common side effects may include:

  • nausea, diarrhea;
  • headache;
  • fever;
  • kidney problems; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ceftolozane and tazobactam?

Other drugs may affect ceftolozane and tazobactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about ceftolozane and tazobactam.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 2.01. Revision date: 6/14/2019.

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